Post Menopausal Osteoporosis: Drug Maintains Bone Density For Over Eight Years

by Laura Ramirez on September 30, 2011

Post menopausal osteoporosis is a growing concern for women who have gone through the change and whose bones are no longer protected by the density-building effects of estrogen. If you’ve been diagnosed with osteoporosis (or it’s predecessor: osteopenia), it is important to understand that this is a serious disease that has long term implications in terms of your ability to hold yourself upright, function properly, move freely and live without pain. (As a woman whose husband lives in chronic pain, I know what a joy sucker pain and disability can be.) Women with severe osteoporosis can have fractures that are ultimately disfiguring.

Although there is no cure, there are ways to treat this disease. Some doctors recommend calcium and weight-bearing exercise along with stretching. Other doctors recommend hormones because as mentioned earlier, estrogen helps build and maintain bone density. Still other doctors prescribe drugs such as Boniva, Fosamax and now, Prolia. (These drugs work by preventing the breakdown of old bone, thus increasing bone density.)

Here’s what an article in has to say about the recent study done on Prolia. This study was a long term study that took place over the past eight years:

Postmenopausal females with osteoporosis or low bone mass who are on Prolia (denosumab) treatment were found to have continued increase in BMD (bone mineral density) for up to eight years, Amgen announced today at the meeting of the American Society for Bone and Mineral Research, San Diego, California

A Phase 2 study extension demonstrated that BMD at the lumbar spine and total hip increased at 16.8% and 6.9% compared to baseline for up to eight years among postmenopausal women with osteoporosis or low bone density who were on denosumab treatment….

post menopausal osteoporosis

Post menopausal osteoporosis can be treated with supplements, exercise and prescription drugs.

Prolia increases bone density by controlling the cells that break down bone called osteoclasts. The drug is given to patients every six months by injection.

When discussing the possibility of taking drugs that prevent the break down of old bone, ask your doctor these important questions: isn’t it important for the body to break down old bone, so that it can build new, stronger bone in its place? If the body is building new bone on top of old bone (that would have otherwise been broken down except for taking the drug), does this create a weakened structure when all is said and done?

What do you think about taking Prolia for post menopausal osteoporosis? Are you taking this drug or a similar drug (like Boniva or Fosamax)? Based on your experience, would you recommend these drugs use to other women? Are there any side effects in particular that you think women should be aware of before they start taking one of these drugs?

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